植物学报 ›› 2001, Vol. 18 ›› Issue (01): 3-10.

• 综述与专论 • 上一篇    下一篇

真核mRNA的3′非翻译区转录后水平调控作用研究进展

江元清 凌毅 赵武玲   

  1. (中国农业大学农业部植物生理生化重点开放实验室 北京 100094)
  • 收稿日期:2000-10-27 修回日期:2000-12-04 出版日期:2001-01-20 发布日期:2001-01-20
  • 通讯作者: 赵武玲

Progress in the Studies on Function of 3′Untranslated Region on Post-transcriptional Level

JIANG Yuan-Qing LING Yi ZHAO Wu-Ling   

  1. (Opening Laboratory of Plant Physiology & Biochemistry in the Ministry of Agriculture, China Agricultural University, Beijing 100094)
  • Received:2000-10-27 Revised:2000-12-04 Online:2001-01-20 Published:2001-01-20
  • Contact: ZHAO Wu-Ling

摘要: 真核生物mRNA的3′非翻译区(3′-UTR)在基因表达的转录后调控中起着重要作用:3′-UTR内存在末端加工信号以指导mRNA3′末端的加工;3′-UTR不但控制mRNA的稳定性及降解速率、协助辨认特殊密码子,而且还控制着mRNA的翻译时间、位点及控制其翻译起始及效率等。

Abstract: The 3′ untranslated region (3′_UTR) of eukaryotic transcripts plays an important role in regulating gene expression on post_transcriptional level. 3′end processing signals which instruct the 3′ end processing exist in 3′_UTR. 3′_UTR not only controls mRNA stability and the rate of mRNA degradation, but also helps to recognize UGA codon which directs the incorporation of rareselenocysteine into proteins. Still, many other signals existing in 3′_UTR determine mRNA localization, regulate translation initiation and translation efficiency as well as translation time, sites, etc.