Plant Diversity ›› 2008, Vol. 30 ›› Issue (05): 617-620.doi: 10.3724 SP.J.1143.2008.07295

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New Inhibitors of Dual-specificity Protein Phosphatase Cdc25C from Plants

JIA Rui-Rui1 , ZENG Guang-Zhi1 , TAN Ning-Hua1, FAN Jun-Ting1 , 2 ,
HUANG Huo-Qiang1 , 2 , JI Chang-Jiu1 , 2 , HAO Xiao-Jiang1 ,
ZHAO Qin-Shi1 , LI Chao-Ming1
  

  1. 1 State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany , Chinese Academy
    of Sciences, Kunming 650204 , China ; 2 Graduate School of the Chinese Academy of Sciences , Beijing 100049 , China
  • Received:2007-12-14 Online:2008-10-25 Published:2008-10-25

Abstract: Protein phosphatase Cdc25C dephosphorylates the mitotic kinase CDK1 cyclin B, and then triggers the cell cycle progression. Overexpression of Cdc25C is detected in some cancer cells, which made it to be a potential target for anti-cancer drugs. Through Cdc25C assay, compounds 1 - 8 were found to be new natural inhibitors against Cdc25C with IC50 s of 1.66 - 75.07
μmol/L. Moreover , 3 , 4 , 5 and 7 exhibited cytotoxicities on a panel of ten cancer cell lines with IC50 s below 10μg/mL.

Key words: Cdc25C

CLC Number: 

  • Q 946