Plant Diversity ›› 2009, Vol. 31 ›› Issue (05): 469-473.doi: 10.3724/SP.J.1143.2009.09111

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Effect of Chemical Constituents from Syzygium cumini (Myrtaceae)
on Glucose Uptake in Insulin-resistant L6 Cells

LI Shi-Fei1 , 2 , HUANG Nian-Xu3 , HAO Xiao-Jiang1 , LI Ling3 , LI Shun-Lin1   

  1. 1 State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany , Chinese Academy of Sciences, Kunming 650204 , China ; 2 Graduate University of Chinese Academy of Sciences , Beijing 100049 , China; 3 Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College , Kunming 650031 , China
  • Received:2009-06-05 Online:2009-10-25 Published:2009-10-25
  • Contact: LI Shun-Lin

Abstract: Eight known compounds isolated from the roots of Syzygium cumini were evaluated for their ability to enhance the glucose consumption in insulin-resistant L6 muscle cells induced by high concentration-insulin and glucose . All of compounds significantly enhanced the glucose consumption of insulin-resistant cells in the presence and absence of insulin. The glucose consumption was increased 17.35% and 51.11% by compound 1 ( friedelin) at a concentration of 10 μg ml-1 without insulin and by compound 8 (5 , 7 , 3′, 4′, 5′-pentahydroxyflavone) at a concentration of 0 . 1μg ml - 1 with insulin, respectively .

Key words: Syzygium cumini

CLC Number: 

  • Q 946