Acta Metallurgica Sinica 2006, 28(05) 543-552 DOI:      ISSN: 0412-1961 CN: 21-1139/TG

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Keywords
Carbonic Anhydrase Ⅱ
Authors
ZENG Guang-Zhi; HUANG Huo-Qiang; TAN Ning-Hua; JI Chang-Jiu; PAN Xu-Lin
PubMed
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Carbonic Anhydrase Ⅱ : Structures , Functions and Inhibitors

ZENG Guang-Zhi; HUANG Huo-Qiang; TAN Ning-Hua; JI Chang-Jiu; PAN Xu-Lin

State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany , Chinese Academy of Sciences

Abstract

Human carbonic anhydrase Ⅱ is one of the most efficient one in carbonic anhydrase isozymes, which catalyzes the reversible hydration dehydration of CO2 and water : CO2 + H2O\ HCO3- + H+. It is found in virtually every tissue
and cell type, and involves in many human physiological and pathological processes, such as human acid-base balance, glaucoma, osteoporosis, and cancer. Since discovered in 1940, carbonic anhydrase Ⅱ has been an important drug target with more attention. Up to now, many inhibitors were discovered including some clinical therapeutic drugs. This paper reviewed recent developments in structures, functions and inhibitors of human carbonic anhydrase Ⅱ.

Keywords Carbonic Anhydrase Ⅱ  
Received 2005-12-05 Revised 1900-01-01 Online:  
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Corresponding Authors: TAN Ning-Hua
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