水朝阳旋覆花中新的细胞毒活性麝香草酚类化合物

doi:10.3724 SP.J.1143.2009.08199

Plant Diversity ›› 2009, Vol. 31 ›› Issue (02): 190-192.DOI: 10.3724 SP.J.1143.2009.08199

• 研究论文 • 上一篇

水朝阳旋覆花中新的细胞毒活性麝香草酚类化合物

黄火强1 , 2 , 谭宁华1, 曾广智1 , 嵇长久1 , 2 , 韩洪金1 , 徐俊驹1 , 2 , 张玉梅1

1 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室, 云南昆明 650204; 2 中国科学院研究生院, 北京 100049

收稿日期:2008-11-04 出版日期:2009-04-25 发布日期:2009-04-25

New Cytotoxic Thymol Derivatives from Inula helianthus-aquatica (Compositae)

HUANG Huo-Qiang¹ ^{, 2} , TAN Ning-Hua¹, ZENG Guang-Zhi¹ , JI Chang-Jiu¹ ^{, 2} , HAN Hong-Jin¹, XU Jun-Ju^{1 , 2} , ZHANG Yu-Mei¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 , China; 2 Graduate University of Chinese Academy of Sciences, Beijing 100049 , China

Received:2008-11-04 Online:2009-04-25 Published:2009-04-25

摘要/Abstract

摘要： 从水朝阳旋覆花( Inula helianthus-aquatica) 的95% 乙醇提取物中分离得到4 个麝香草酚类化合物, 其中化合物1 为新化合物。它们的化学结构通过波谱方法鉴定为: 8-hydroxy-9 , 10-dioxyisopropylidene-thymol (1) , 10-hydroxy-8 , 9-dioxyisopropylidene- thymol (2) , 8-hydroxy-9 , 10-diisobutyryloxy- thymol ( 3) 和8 , 10-dihydroxy-
9-isobutyryloxy- thymol (4)。肿瘤细胞毒试验结果表明它们在6 种肿瘤细胞株上(K562 , HT-29 , SGC-7901, DU145 , MDA-MB-231 , U251 ) 显示一定的细胞毒活性, 其中化合物2 活性最强, 它的IC50 值为4 . 20～33 . 12 μmol/L。具有细胞毒活性的麝香草酚类化合物是首次在该种植物中发现。

关键词: 水朝阳旋覆花, 麝香草酚类化合物, 细胞毒活性

Abstract: A new thymol derivative, 8-hydroxy-9 , 10-dioxyisopropylidene- thymol (1 ) , together with three known thymol derivatives 10-hydroxy-8, 9-dioxyisopropylidene-thymol (2 ) , 8-hydroxy-9 , 10-diisobutyryloxy- thymol ( 3 ) and 8 , 10-dihydroxy-9-isobutyryloxy- thymol (4) , was isolated from 95% EtOH extract of the flowers of Inula helianthus-aquatica. Their structures were elucidated on the basis of detailed spectroscopic analysis . These compounds showed cytotoxicities on six cancer cell lines (K562 , HT-29 , SGC-7901, DU145, MDA-MB-231 , U251) , and compound 2 is the strongest one with IC50s of 4 .20 - 33. 12μmol􊄯L . This is the first time that the cytotoxic thymol derivatives were isolated from this titled plant .

Key words: Inula helianthus-aquatica

中图分类号:

Q 946

黄火强1 , 2 , 谭宁华1, 曾广智1 , 嵇长久1 , 2 , 韩洪金1 , 徐俊驹1 , 2 , 张玉梅1 . 水朝阳旋覆花中新的细胞毒活性麝香草酚类化合物[J]. Plant Diversity, 2009, 31(02): 190-192.

HUANG Huo-Qiang ^, , TAN Ning-Hua, ZENG Guang-Zhi , JI Chang-Jiu ^, , HAN Hong-Jin, XU Jun-Ju^, , ZHANG Yu-Mei. New Cytotoxic Thymol Derivatives from Inula helianthus-aquatica (Compositae)[J]. Plant Diversity, 2009, 31(02): 190-192.

水朝阳旋覆花中新的细胞毒活性麝香草酚类化合物

New Cytotoxic Thymol Derivatives from Inula helianthus-aquatica (Compositae)

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