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Plant Diversity ›› 2008, Vol. 30 ›› Issue (03): 378-380.DOI: 10.3724 SP.J.1143.2008.07289

• 研究论文 • 上一篇    下一篇

以细菌中烯醇式丙酮酸转移酶为作用靶点的新天然抑制剂

姜立花, 谭宁华, 曾广智, 郝小江, 张颖君, 邱明华   

  1. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室, 云南昆明 650204
  • 收稿日期:2007-12-12 出版日期:2008-06-25 发布日期:2008-06-25
  • 通讯作者: 谭宁华,曾广智

New Natural Inhibitors Targeting Bacterial Enolpyruvyl Transferase

JIANG Li-Hua, TAN Ning-Hua, ZENG Guang-Zhi, HAO Xiao-Jiang , ZHANG Ying-Jun , QIU Ming-Hua   

  1. State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 , China
  • Received:2007-12-12 Online:2008-06-25 Published:2008-06-25
  • Contact: TAN Ning-Hua,ZENG Guang-Zhi

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摘要： 肽聚糖是细菌细胞壁的重要成分, 烯醇式丙酮酸转移酶(EPT) 是调节肽聚糖合成初始阶段的关键酶。通过活性筛选, 发现了三个对EPT 有抑制活性的天然产物( 化合物1～3) , 它们皆为EPT 的新抑制剂。体外抗真菌实验发现, 化合物2 和3 对光滑念珠菌具有较好的生长抑制作用。另外, 化合物3 还具有一定的肿瘤细胞毒活性。

关键词: 烯醇式丙酮酸转移酶, 天然抑制剂, 细胞壁, 抗菌

Abstract: Bacterial enolpyruvyl transferase (EPT) is one of the key enzymes acting in the initial stage of peptidoglycan synthesis of bacterial cell walls . Through inhibition assay, three new natural inhibitors (1 - 3) were found against EPT . Inhibitor 2 and 3 showed antifungal activities against fungus Candida glabrata, and inhibitor 3 showed cytotoxicities against several cancer cells .

Key words: Enolpyruvyl transferase

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