New Natural Inhibitors Targeting Bacterial Enolpyruvyl Transferase

doi:10.3724 SP.J.1143.2008.07289

Plant Diversity ›› 2008, Vol. 30 ›› Issue (03): 378-380.DOI: 10.3724 SP.J.1143.2008.07289

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New Natural Inhibitors Targeting Bacterial Enolpyruvyl Transferase

JIANG Li-Hua, TAN Ning-Hua, ZENG Guang-Zhi, HAO Xiao-Jiang , ZHANG Ying-Jun , QIU Ming-Hua

State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 , China

Received:2007-12-12 Online:2008-06-25 Published:2008-06-25
Contact: TAN Ning-Hua,ZENG Guang-Zhi

Abstract

Abstract: Bacterial enolpyruvyl transferase (EPT) is one of the key enzymes acting in the initial stage of peptidoglycan synthesis of bacterial cell walls . Through inhibition assay, three new natural inhibitors (1 - 3) were found against EPT . Inhibitor 2 and 3 showed antifungal activities against fungus Candida glabrata, and inhibitor 3 showed cytotoxicities against several cancer cells .

Key words: Enolpyruvyl transferase

CLC Number:

Q 946

JIANG Li-Hua, TAN Ning-Hua, ZENG Guang-Zhi, HAO Xiao-Jiang , ZHANG Ying-Jun , QIU Ming-Hua. New Natural Inhibitors Targeting Bacterial Enolpyruvyl Transferase[J]. Plant Diversity, 2008, 30(03): 378-380.

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New Natural Inhibitors Targeting Bacterial Enolpyruvyl Transferase

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