Plant Diversity ›› 2008, Vol. 30 ›› Issue (05): 621-623.DOI: 10.3724 SP.J.1143.2008.07305

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New Natural Inhibitors of Human Cathepsin B

JIA Rui-Rui, ZENG Guang-Zhi, TAN Ning-Hua, ZHOU Zhi-Hong, ZHANG Ying-Jun   

  1. State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
  • Received:2007-12-20 Online:2008-10-25 Published:2008-10-25
  • Contact: TAN Ning-Hua

Abstract: Cathepsin B is an important member of the papain-like cysteine proteases . It has been implicated in the pathology of many human diseases, especially in the invading and metastasis of most malignant tumors. With random screening, five natural compounds, prodelphinidin B-2 3′-O-gallate (1 ) , prodelphinidin B-2 ( 2), procyanidin B-2 ( 3), puerin A (4) and (- ) epigallocatechin-3-O-gallate ( 5 ) , were found to show potent cathepsin B inhibitory activity with IC50 s of 0.58, 0.44, 0.76, 2.07 and 0.96μmol/L, respectively. Inhibitors 1 - 5 are found with chemotype of flavanols, which are
new natural inhibitors of cathepsin B.

Key words: Cathepsin B

CLC Number: