Abstract: In this paper the isolation and the structure elucidation of tow new diter- pene lactones, hypolide C20H24o3 (1) and tripterolide C20H24o7(V) are repoted. Hypolide was iso1ated from T. hypoglucum (Levl) Hutch. with yield 0.0005%, and from T. regelii Spzagus et Takeda, T. forestii Dicls, T. wilfordii Hook. The elementa1 analysis, UV, IR, MS, NMR spectra data and derivatives of methylation, hydrogenation have indicated it to be diterpene α,β-unsaturated-γ-lactone, and no peresence of epoxide groups, ring-C to be a substittuted arom-atic ring. After methylation with dimethyl sulfate, the ring-C similar to the intermediate product (Ⅶ) of the total synthesis of triptolide.

Key words: Diterpen lactones