Plant Diversity ›› 2014, Vol. 36 ›› Issue (04): 545-550.DOI: 10.7677/ynzwyj201413182

• Articles • Previous Articles    

A New Cytotoxic Oxyneolignan from the Roots and Stems of Clausena lansium (Rutaceae)*

 SONG  Wei-Wu-1、2, ZENG  An-Zhi-1, PENG  Wen-Wen-1, TAN  Ning-Hua-1   

  1. 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy
    of Sciences, Kunming 650201, China; 2 University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2013-09-16 Online:2014-07-25 Published:2013-10-10
  • Supported by:

    Found of the National New Drug Innovation Major Project of China (2011ZX0930700202), the National Natural Science Foundation of China (U1032602 and 91013002), the National Basic Research Program of China (2009CB522300), the Fund of Chinese Academy of Sciences (Hundred Talents Program), and the Natural Science Foundation of Yunnan Province (2012GA003)


 A new oxyneolignan, claulignan (1), together with seven known compounds (2-8), were isolated from the methanol extract of the roots and stems of Clausena lansium. Their structures were elucidated on the basis of 1D and 2DNMR experiments and mass spectrometry. Compounds 2-8 were isolated from the genus Clausena for the first time. Compounds  1 and 6 showed cytotoxicity against human cervical cancer HeLa cell line with the IC50values of 2503 and 5399μM, respectively. Compound 3 exhibited antioxidant activity in the DPPH assay with the EC50 value of 26896g·kg-1.

Key words:  Clausena lansium, Oxyneolignan, Cytotoxicity, DPPH, Claulignan

CLC Number: