Abstract: Subchtaneous injection of total saponins from Psammasilene tunicoides, at a dose of 5 mg/kg, raised the paia threshold significantly (P <0.001) in the expe-riment on mouse by "Hot-Plate" method, as well as significantly lessened the fre- quency of "Writhing" response induced by 0.6%,acetic acid in mice. Psammosilene tunicoides saponins could inhibit the croton oil induced infla- mmation of the ear in mice, and the granuloma caused by cotton.In vitro, Psa- mmosilene tunicoides saponins had a definite inhibitory action on Staphyloco- ccus, Escherichia coll, Pseudomonas aeruginosa, Candida albicans, Trichoph- yton tonsurans, Trichophyton gypseum, and Sporotrichum schenekii.

Key words: Pharmacological, activity, total, saponins, psammosilene