Abstract: From the roots of Panax notoginseng fourteen cyclodipeptides 1-14 were isolated including one new compound (1),seven new natural compounds (4-10) and six known compounds (2-3,11-14) together with one known other compound 15.The chemical structure of 1 was elucidated as cyclo(LeuThr) based on spectral methods.From the roots of Panax ginseng five known lactams (16-20) including pyroglutamic acid were isolated together with butyric diacid,daucosterol and sucrose.The primary bioactivity test showed that pyroglutamic acid and its nbutyl derivative have weak Ca2+ antagonistic activity.

Key words: Panax notoginseng