Abstract: Two new labdanoids, forskolin E and F, with forskolin A, B, C and D, have been isolated from the chloroform extract of the whole plants of Coleus forskohlii. The chemical structures of the two minor constituents have been established as lα, 7β- diacetoxy- 8,13 epoxy- 6β- hydroxylabd- 14- en- 11 - one(l) and 7β-acetoxy- 8,13 - epoxy- 6β,9a- dihydroxylabd - 14- en- 11 - one(2), respectively, on the basis of detailed spectroscopic analysis and all assignments were supported by 1H -1H COSY, HMBC and HMOC spectrum (see table 1).

Key words: Forskolin E and F