Plant Diversity ›› 2006, Vol. 28 ›› Issue (05): 543-552.
• Articles •
ZENG Guang-Zhi; HUANG Huo-Qiang; TAN Ning-Hua; JI Chang-Jiu; PAN Xu-Lin
Human carbonic anhydrase Ⅱ is one of the most efficient one in carbonic anhydrase isozymes, which catalyzes the reversible hydration dehydration of CO2 and water : CO2 + H2O\ HCO3- + H+. It is found in virtually every tissueand cell type, and involves in many human physiological and pathological processes, such as human acid-base balance, glaucoma, osteoporosis, and cancer. Since discovered in 1940, carbonic anhydrase Ⅱ has been an important drug target with more attention. Up to now, many inhibitors were discovered including some clinical therapeutic drugs. This paper reviewed recent developments in structures, functions and inhibitors of human carbonic anhydrase Ⅱ.
Carbonic Anhydrase Ⅱ
ZENG Guang-Zhi; HUANG Huo-Qiang; TAN Ning-Hua; JI Chang-Jiu; PAN Xu-Lin. Carbonic Anhydrase Ⅱ : Structures , Functions and Inhibitors[J]. Plant Diversity, 2006, 28(05): 543-552.
Add to citation manager EndNote|Ris|BibTeX