Plant Diversity ›› 2007, Vol. 29 ›› Issue (06): 717-721.

• Articles • Previous Articles    

Synthesis of Isatin Derivatives and the Biological Activity Against the Magnaporthe grisea

CHEN Gang1 , 4 , WANG Ye2 , HE Hong-Ping1 , LI Shun-Lin1 ,
ZHOU Li-Gang3 , HAO Xiao-Jiang1 , 2   

  1. 1 State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 , China ;

    2 Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002 , China ;
    3 College of Agronomy and Biotechnology , China Agricultur1 al University , Beijing 100094 , China;
    4 Graduate University of Chinese Academy of Sciences, Beijing 100049 , China

  • Received:2007-05-14 Online:2007-12-25 Published:2007-12-25
  • Contact: HAO Xiao-Jiang

Abstract:

A series of 3-imine􊄯methylene-indole-2-one compounds was synthesized from isatin , and their activity on inhibition of germination of Magnaporthe grisea spores was evaluated . It was found that the hydroxymethyl and aminomethyl of N, and the methylene on C3 might be the pharmacophore . The p-substitute , hydroxy , and electron withdraw group of the aryl
methylene lead to poor activity , while the o- electron donor group leads to potent activity .

Key words: Magnaporthe grisea

CLC Number: