Plant Diversity ›› 2007, Vol. 29 ›› Issue (04): 486-488.

• Articles • Previous Articles    

Gallic Acid Esters of Bergenin from Saxifraga melanocentra (Saxifragaceae) and Their Inhibition Against HCV NS3 Protease

ZUO Guo-Ying1 , 2 , LI Zheng-Quan1 , Chen Li-Rong1 , HE Hong-Ping3 , XU Xiao-Jie1   

  1. 1 College of Chemistry and Molecular Engineering , Yangshengtang Nature Medicine Laboratory , Peking University, Beijing 100871 , China ; 2 Kunming General Hospital , Kunming 650032 , China; 3 The State Key Laboratory
    of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 , China
  • Received:2006-10-11 Online:2007-08-25 Published:2007-08-25
  • Contact: XU Xiao-Jie

Abstract: To study the chemical and bioactive characteristics of bergenin derivatives which were purified from Saxifraga melanocentra Franch ., a new gallic acid ester of bergenin , 11- O- (4 - O-methylgalloyl) bergenin (1) was isolated from the aerial parts of Saxifraga melanocentra Franch ., and its structure was established mainly on the basis of 1D and 2D NMR spectroscopic analysis . It showed weak inhibitory activity against HCV NS3 serine protease with IC50 of 0.32mg/ml .

Key words: HCV NS3 serine protease

CLC Number: