Plant Diversity ›› 1983, Vol. 5 ›› Issue (01): 1-3.

• Articles •    

CHROMAT0GRAPHIC FRACTIONATI0N AND MASS-SPECTRONIETRIC DETECTION 0F THE ANSAMACR0LIDES OF MAYTANSINOID 1. Isolation and characterization of three antitumor agents from two Plants of Maytenus

Li Chaomin, Zhu Jixiang,Zhou Yunli, Huang Liying   

  1. Yunnan Institute of Tropical Botany, Academia Sinica;Shanghai Institute of Materia Medica, Academia Sinica
  • Online:1983-02-25 Published:1983-02-25

Abstract: Recently we have applied the method of column chromatography, prepara-tive thin layer chrornatography(PTLC), high performance liquid chromatography (HPLC) combined with mass-spectrometric detection, which enables us to finish the isolation and characterization of this kind of antitumor agents from 1-2 kg of sample of the plant within 1-2 months. In this experiment, we have successfully isolated and identified maytansine (I), maytanprine (II) and maytanbutine (III) from Maytenus austroyunnan- ensis S. J. Pei & Y. H. Li. and M. berberoides (W. W. Sm) S. J. Pei & Y. H. Li. respectively in this way.

Key words: chromatographic, fraction, maytansinoid